Biobank

Automated system for purification of cell subsets using immunomagnetic procedures. The instrument and applied technology allow isolation or enrichment of virtually any cell type, including from whole blood, with well-standardized procedures. It allows separation of up to 10 million cells per second, from 105 up to 109 total cells in volumes ranging from 0.2 to 50 mL. It is possible to work with many samples simultaneously and obtain from the same sample the positively selected population (even more than one), the depleted, and the unaltered.

TECHNICAL SPECIFICATIONS AND FEATURES:

• Allows separation of up to 10 million cells per second, from 105 up to 109 total cells in volumes ranging from 0.2 to 50 ml.

• It can process many samples simultaneously.

• It is possible to separate the positively selected population (even more than one), the depleted, and the unaltered from the same sample.

An advanced system for the three-dimensional culture of spheroids and organoids. Cells are seeded and cultured within dedicated 50 mL tubes, which are subjected to a gentle and continuous bidirectional rotation. This motion ensures homogeneous growth and keeps the forming cell aggregates in suspension throughout the culture process.

The instrument can simultaneously accommodate up to four independent tubes, each operating under custom growth protocols, including individually controlled temperature, pH, CO₂, humidity, and rotation settings.

Thanks to its automated control of environmental parameters, CERO 3D functions as a true bioreactor, enabling the reproducible generation of complex biological models with minimal manual intervention.

The 3D culture environment more closely mimics physiological conditions compared to traditional 2D culture systems, making it an ideal platform for studies involving toxicity, disease modeling, drug development, developmental biology, and precision medicine.

A fully automated and standardized single-cell biological tissue dissociation instrument that can handle up to eight samples simultaneously and independently. Single-cell suspensions are obtained in special tubes that allow sample preparation in a closed, sterile system, ensuring a high level of operator safety and minimizing cross-contamination. The tool has several preset programmes, and new user-defined programs can be set up to create fully automated workflows for many tissue types.

TECHNICAL SPECIFICATIONS AND FEATURES:

• Preset and customized programs to dissociate various tissue types into single cell suspensions.

• Total device automation minimizing the need for manual intervention.

• Versatility and adaptation to a wide range of applications, including sample preparation for flow cytometry, cell culture and molecular analysis.

• Simultaneous processing of multiple, even different samples.

A highly versatile platform for immunoassays, leveraging magnetic bead technology to enable the comprehensive, rapid, and precise quantification of multiplex analyte panels (up to 100 analytes simultaneously) from minimal sample volumes (as little as 25 µL), across a wide range of biological sample types.

TECHNICAL SPECIFICATIONS AND FEATURES:

Detection and quantification of biomarkers, suitable for monitoring cellular responses to in vitro treatments.

Simultaneous analysis of tumor-associated proteins, including those involved in angiogenesis, metastatic progression, circulating tumor markers, and key molecules defining the tumor microenvironment.

The computerised banking system, Biobanking Solution, combined with the cryopreservation system for cell/tissue samples in automated refill nitrogen vials, guarantees the confidentiality of the contained clinical data and the anonymity of the samples, which are only traceable by the operator via a barcode reader. More than 10,000 vials of vital samples can be stored in a single container.

The Biobank service also benefits from being situated in specialized premises with controlled access, which guarantees optimal isolation from external contamination.

A real-time cell monitoring system that operates on label-free, continuous impedance-based measurements. It uses microelectrodes integrated into the bottom of well-dedicated plates, allowing for the continuous recording of dynamic cellular changes.

The impedance signal intensity reflects various parameters, including the number of adherent cells, cell adhesion, and morphology, enabling the monitoring of cellular proliferation and migration in real time.

The system features three independent platforms, allowing for the simultaneous execution of three separate experiments using 16-well plates specifically designed for the instrument.

There are two main types of assay plates:

E-Plate (Electronic Plate): Equipped with integrated gold microelectrodes at the bottom of each well, this plate is used for standard real-time monitoring of cell morphology, proliferation, and cytotoxicity.

CIM-Plate (Cell Invasion and Migration Plate): Designed with a dual-chamber Transwell®-like structure, separated by a porous membrane, and used for advanced cell migration and invasion studies, particularly in the fields of oncology and immunology.

During the experimental procedure, the instrument is placed inside a standard CO₂ incubator to maintain optimal culture conditions.